Abstract: Diabetic nephropathy (DN) is a common complication of diabetes and is currently one of the main cause of endstage renal disease, the pathogenesis of which is still unclear. In recent years, many animal experiments and clinical studies have found that cellular senescence plays a pivotal role in the development of DN. The mechanisms of cellular senescencerelated damage such as telomere attrition, mitochondrial dysfunction, autophagy, inflammatory response, mTOR signaling pathway, Sirtuins activation, and coagulation factors release are important for the disease progression of DN. In this paper, we focus on the factors related to cellular senescence in the process of DN. Moreover, we emphasize the potential therapeutic targets of cellular senescence in DN to provide new research ideas for its treatment.