Abstract: Systemic lupus erythematosus (SLE) is a typical autoimmune disease with high morbidity and mortality.The production of inflammatory factors and autoantibodies is closely related to the pathogenesis of SLE.It has been found that the number of TCR αβ+CD3+CD4-CD8-T cells (DNT cells) in the peripheral blood of SLE patients is significantly increased and related to the activity of SLE,but its origin and function are still unclear and controversial.More and more studies suggest that the overexpression of  cAMP responsion element modulator (CREM) α in DNT cells and the activation of mammalian target of rapamycin (mTOR) are key factors in the pathophysiology of SLE.This article mainly introduces the origin,functional characteristics and the role of double negative T cells in SLE,in order to find a new way to treat the disease.

Key words: TCR &alpha, &beta, +CD3+CD4-CD8-T cells,systemic lupus erythematosusc,AMP-responsive element modulator &alpha, ,mammalian target of rapamycin