Abstract: Calciphylaxis is a fatal painful ischemic cutaneous necrotic disease and mainly occurred in maintenance dialysis patient.Typical histopathological features are systemic arteriolar membranous calcification,intimal fibrosis and thrombosis so that skin biopsy is the golden standard of diagnosis.Therefore,calciphylaxis is also known as calcific uremic arteriolopathy (CUA).Calciphylaxis is a rare disorder with poor prognosis and there is no guidance or consensus of the treatment currently.However,on the basis of cases reports and clinical studies,systematic treatments including reducing or eliminating risk factors,pain management,wound care,medication and hyperbaric oxygen therapy have been gradually formed.This article reviews the recent retrospective data and clinical experience of treatment in calciphylaxis to help with the standardized management.