Abstract:

Kidney clearance capacity is deteriorated in patients with chronic kidney disease (CKD),accumulation of uremic toxins (UTs) exert toxic effects on many vital organs,especially the cardiovascular system.Proteinbound uremic toxins (PBUTs) is an important factor in the occurrence and development of cardiovascular disease (CVD).It is of great clinical significance to fully understand the anabolism,biotoxicity,and clearance methods of PBUTs for studying the mechanism of CVD.Thus we reviewed the references,in order to illuminate the characteristics of PBUTs toxins and the mechanism of CVD in patients with CKD.

Key words: protein-bound uremic toxins, chronic kidney disease, cardiovascular disease