Abstract:

Diabetic kidney disease is a major microvascular complication in diabetes, and the clinical features is persistent proteinuria and (or) decline of glomerular filtration rate. It was found that compared to glomerular disease, the correlation between renal tubular injury and renal function deterioration of diabetic kidney disease is higher. microRNA (miRNA) is a group of short noncoding RNAs, which has become a new direction in the research field of diabetic kidney disease, and it has been proved to be related to the occurrence and development of diabetic kidney disease. miRNA is involved in tubuleinterstitial fibrosis, leading to renal tubular injury and dysfunction. The purpose of this review is to summarize the research achievements about the mechanism of miRNA involved in the pathological and physiological processes of diabetic kidney disease.