Chinese Journal of Nephrology, Dialysis & Transplantation ›› 2017, Vol. 26 ›› Issue (3): 229-234.DOI: 10.3969/cndt.j.issn.1006-298X.2017.03.006
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Objective:To evaluate the predictive value of brachialankle pulse wave velocity (baPWV) for major adverse cardiovascular events (MACE) in patients with peritoneal dialysis. Methodology:A total of one hundred three end stage renal (ESRD) patients with peritoneal dialysis over 3 months were enrolled into this study. Their baseline characteristics, baPWV and other laboratory measurements were collected and analyzed. According to the patients whether or not suffered from MACE, they were divided into two groups: MACE group (n=29) and nonMACE group (n=74). Results:The patients in MACE group had significantly higher baPWV(1 943±479 cm/s vs 1 542±325 cm/s,P<0001), Ischemia modified albumin(IMA) levels and high sensitivity Creactive protein (hsCRP) and lower 24h urine volume, serum albumin, total creatinine clearance, residual GFR(rGFR). Multivariable logistic regression analysis results showed that baPWV, IMA and hsCRP were independent risk factors for MACE. From ROC (receiver operating characteristic) curve analysis, the optimal cutoff of baPWV to predict MACE was 1 714 cm/s, with a sensitivity of 6897% and a specificity of 8493% [area under the curve, 0787 (95% confidence interval, 0695,0862); Z=5592,P<005.] Then, two groups were devided. 71 patients had normal baPWV (baPWV<1 714 cm/s) and were assigned the normal baPWV group, and the other 32 patients were assigned to high baPWV group (baPWV≥1 714 cm/s) . Survival analysis showed that there were significant difference between two groups in nonMACE survival(Log rank statistic χ2=3307,P<0001). Conclusion: BaPWV can be used as a predictor of peritoneal dialysis patients with MACE.
SU Xiaoyan,DING Su,ZHENG Weiping, et al. Predictive value of brachialankle pulse wave velocity for cardiovascular events in peritoneal dialysis patients[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2017, 26(3): 229-234.
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URL: http://www.njcndt.com/EN/10.3969/cndt.j.issn.1006-298X.2017.03.006
http://www.njcndt.com/EN/Y2017/V26/I3/229