Abstract:

ABSTRACT Gout is a kind of inflammatory arthritis resulted from long term purine metabolic disturbance, with hyperuricaemia as its key biochemical basis. The genome-wide association studies (GWAS) and meta analysis have found many genes which are relevant with hyperuricaemia. Three of these genes have been studied sufficiently, including SLC2A9, ABCG2, and SLC22A12. SLC2A9 encodes GLUT-9, which participates in the regulation of uric acid reabsorption at the proximal tubule. ABCG2 protein plays a role in the process of the apical secretion of urate. SLC22A12 encodes URAT1, which is also responsible for the reabsorption of urate. In this paper, through discussing the relationship between these genes and hyperuricaemia, the molecular mechanisms about the regulation of uric acid excretion will be investigated.

Key words: hyperuricaemia, genome, molecular mechanisms