Abstract:

ABSTRACT Objective: To observe the effect and the side-effect of the conversion from MMF to mizoribine (MZR) after renal transplantation. Methodology: Sixteen kidney recipients with high risks of infection (ATG induction before operation, age over 60 years, MP pulse over 3g, the blood lymphocyte count was less than 1000/ul) were enrolled his study. Their initial immunosuppressive protocol was tacrolimus combined with MMF and predinisone. The conversion from MMF to MZR happened during 4 to 6 weeks after operation. The period of observation lasted to six months. The WBC count, rate of lymphocyte, and the lymphocyte count in peripheral blood were collected before and after the conversion. The serum creatinine, uric acid and the liver function were collected. The acute rejection and all the kinds of infections were also collected during the observation period. The selected patients received the protocol biopsy on the sixth month. The histological and laboratory tests were analyzed during the sixth month. Results: The WBC count, rate of lymphocyte, and the lymphocyte count in peripheral blood increase after the conversion of the immunosuppressive. The serum creatinine, uric acid and the liver function were stable. One recipients experience the upper respiratory infection and 2 had urinary tract infection. None of them had the severe infection in those high risks recipients. 15 patients were performed the protocol biopsy in the six month. One was diagnosed as subclinical acute rejection with treatment of MP pulse therapy, one board line change, and the other 13 patients were normal changes. Conclusion: The conversion from MMF to MZR happened during 4 to 6 weeks after operation in the kidney recipients with high risks of infection after renal transplantation can reduced the severe infection, and which didn’t increase the rate of acute rejection, with fewer side-effect.