Abstract:

ABSTRACT   FGF23（fibroblast growth factor 23）is a hot topic in regulation of the calcium and phosphate metabolism. The classical effects of FGF23 in the kidney and parathyroid glands are mediated by its binding to FGF receptors (FGFRs) complexed to the co-receptor klotho, maintaining the calcium and phosphate homeostasis with the help of other regulators: PTH,1,25（OH）2D3, and klotho. CKD is a clinical condition in which FGF23 levels are most markedly elevated. Elevated FGF23 level may have an ‘off-target’ direct toxicity in the heart, which may in part explained observations that CKD patients with elevated FGF23 level shown independently association with progression of CKD and development of cardiovascular events and mortality. Therapeutic strategies targeting FGF23 reduction may be helpful in improving outcomes for patients with CKD.

Key words: KEY WORDS  , fibroblast growth factor 23, calcium and phosphate metabolism, chronic kidney decease, outco