Abstract:

ABSTRACT  Objective: To observe early postoperative renal function changes and its influence factors in living-related kidney donors.   Methodology: Thirty four cases of living-related kidney donors were enrolled in this study. Estimated glomerular filtration rate (eGFR) was calculated using the abbreviated Modification of Diet in Renal Disease (aMDRD) formulae, the GFR of both kidneys was detected using emission computed tomography (ECT) equipment and eGFR of each kidney before surgery was estimated in proportion. The changes of eGFR and compensatory rate of the retained kidney in the first month after donor nephrectomy were observed, and at the same time the influence factors [eg, sex, age, body mass index (BMI) and preoperative eGFR] were exanimated. The endpoint of the study was one month post surgery. Results: The eGFR of the retained kidney increased gradually and reached a peak at 4 days after surgery. The average eGFR increased from 72.4 ml/min before surgery to 88.1 ml/min at the endpoint with the average compensatory rate of 21.6%. The eGFR of the male group increased from 64.5 ml/min to 80.5ml/min, with the compensatory rate of 24.8%, and the female group from 76.7 ml/min to 92.2ml/min, with the compensatory rate of 20.2%. For donors over the age of 50, the eGFR increased from 72.8 ml/min to 81.66 ml/min and the compensatory rate was 12.14%, and for doners less than 50 years old the eGFR increased from 72.2 ml/min to 91.5 ml/min with the compensatory rate of 26.8%. For doners eGFR above 60 ml/min before surgery, the average eGFR increased from 81.9 ml/min to 95.4 ml/min with the compensatory rate of 16.4%, and for doners eGFR below 60 ml/min increased from 54.9 ml/min to 74.6 ml/min, with the compensatory rate of 35.8%. For doners BMI above 23.0 kg/m2 before surgery, the average eGFR increased from 67.2 ml/min to 84.4 ml/min, with the compensatory rate of 25.6%, and the eGFR of donors with a presurgry BMI below 23.0 kg/m2 increased from 76.5 ml/min to 90.9 ml/min, with the compensatory rate of 18.9%.  Conclusion: The eGFR of the retained kidney increased significantly after surgery. The; gender, age and preoperative eGFR were important influence factors on the renal recovery of the retained kidney after nephrectomy. The compensatory rate between male and female donors was similar while male donors had a lower preoperative eGFR. Donors over the age of 50 had lower compensatory rate and donors with lower preoperative GFR and higher BMI always had higher compensatory rate.

Key words: Key words  , living-related kidney transplant  , donor  , glomerular filtration rate (GFR)