Abstract:

Abstract:   The renin angiotensin system( RAS) plays an important role in the development of kidney disease. especially high expression in local RAS[1]. Along with the further research of RAS gradually, a new RAS was found besides the classical RAS: Angiotensin Converting-Enzyme 2-Angiotensin-(1-7)-Mas receptor axis (ACE2-Ang (1-7)-Mas axis). Interacted with the classical RAS, they regulate the internal environmental stability and maintain normal renal function [2]. This review will focus on the role of ACE2-Ang (1-7)-Mas axis in the physiology and the pathogenesis of kidney disease.

Key words: angiotensin converting-enzyme 2, -angiotensin-(1-7), Mas receptor, The renin angiotensin system