Abstract:

ABSTRACT  Autophagy is the degradation process of proteins and organelles, mediated by the lysosome, and involves cleaning up aging and damaged organelles or protein and maintaining cellular homeostasis. Autophagy as a highly conserved cell behavior could be observed in almost all species: cell growth, proliferation, and tumorigenesis. There is also basis autophagy in normal kidney tissue, the deregulation of autophagy could lead to renal inherent cell injury and various kidney diseases. The role of autophagy in kidney disease has been recognized recently. This paper reviews the regulation of autophagy and autophagy in kidney disease, and provides a new idea to the research of mechanisms and treatment of some kidney disease.

Key words: Key words , autophagy , kidney disease  , autophagy associated gene/protein