Abstract:

ABSTRACT   The development of peritonitis, the decline of residual kidney function, and the loss of peritoneal membrane function are central events for patients with peritoneal dialysis and affect technique survival. These are closely correlated with the poor biocompatibility of conventional peritoneal dialysis (PD) solutions containing high concentration of glucose, glucose degradation products (GDPs) coupled with the hyperosmolarity, reduced pH, and use of lactate as the buffer. Therefore, the use of neutral pH, low-GDP (NpHLGDP), bicarbonate-buffered PD solutions may represent a promising strategy to attenuate some of these adverse effects. In this article, we will highlight evidence regarding the biocompatibility of NpHLGDP PD solutions and compare the advantage and disadvantage of NpHLGDP PD solutions with traditional PD solutions, review the utility of current biomarkers in the evaluation of biocompatibility, and discuss the clinical outcome data with these solutions.

Key words: Peritoneal dialysis solutions  , biocompatibility  , glucose degradation products residual kidney function