Abstract:

 Objective：To investigate the expression of B lymphocyte stimulator (BlyS) in the renal tissues of patients with primary Sjögren syndrome （pSS）.  Methodology：All patients，who diagnosed as pSS and admitted to our hospital，were retrospectively analyzed. Renal biopsy was performed on 34 patients. The expression of BlyS in the renal tissues was detected by indirect immunofluorescence. The renal tissues from 5 healthy people were selected as normal controls. One way ANOVA analysis was used for the statistics.  Results： Immunofluorescence revealed that BlyS was expressed in the inflammation cells distributed in both renal interstitium and glomerulum, but there was hardly no BlyS expression in normal controls. The expression density of BlyS in patients with hypergammaglobulin was significantly higher than that in patients with normal serum IgG（P=0.03）. Conclusion：BlyS was expressed in the inflammation cells distributed in both renal interstitium and glomerulum The expression of BlyS in the renal tissues of pSS patients was significantly higher than that of normal controls. The level of serum IgG affected the expression level of BlyS in renal biopsied sections.