Abstract: Ｏｂｊｅｃｔｉｖｅ：To observe the impact of intravitreal vascular endothelial growth factor inhibitors(VEGF) on renal damage among diabetic patients.
Ｍｅｔｈｏｄｏｌｏｇｙ：This study retrospectively analyzed the characteristic of renal injury following intravitreal VEGF inhibitors therapy in 9 patients with diabetic retinopathy (DR) stage ⅢⅤ.
Ｒｅｓｕｌｔｓ：After intravitreal VEGF inhibitors injection,1 patient with preexisting hypertension merely presented with clinical and pathological character of thrombotic microangiopathy (TMA),1 patient with preexisting proteinuria presented with elevation of blood pressure，renal biopsy showed a pattern of diabetic nephropathy.The other 7 patients with preexisting proteinuria and hypertension presented with accelerated renal damage progression,worsening proteinuria and renal function,elevated blood pressure,and 1 of them developed myocardial infarction. Renal biopsies proved diabetic nephropathy in 2 of the 7 patients. Dosage of antihypertensive agents increased in all 9 patients. Additional corticosteroids was administered to the patient with TMA. With a median followup of 149 month,the TMA patient acquired negative proteinuria and partial recovery of renal function.The patient with preexisting proteinuria merely presented with stable renal function.Renal function sustained deteriorated in the other 7 patients,and 3 of them progressed to ESRD.Ｃｏｎｃｌｕｓｉｏｎ：Intravitreal VEGF inhibitors therapy in DR patient may accelerate renal damage progression or induce de novo renal injury and hypertension. More attention should be focused on the possible adverse events during intravitreal VEGF inhibitors therapy in DR patient.