Abstract: 68yearold woman entered our hospital complaining of acute discomfort,obtaining dysemesia,anorexia,polydipsia,polyuria,and multiple arthralgia of both lower limbsSeveral weeks before admission,she suffered with right distal radius fracture after accidental fall.The blood test showed hypercalcemic crisis,elevated serum creatinine and parathyroid hormone (PTH)Bone density measurement showed severe osteoporosis.Doppler ultrasonography showed a cystic mass on the inferior pole of the right lobe of  thyroid and calcinosis in the left kidney.After symptomatic treatment,her calcium concentration decreased and renal function improvedShe received right parathyroidectomy and bilateral thyroidectomy,and the pathological examination confirmed right parathyroid adenoma and papillary thyroid carcinoma.