Abstract:

Semaphorin 3A is a kind of secretory proteins in the family of axondirected factors, which play an important role in the course of podocyte differentiation, glomerular filtration barrier formation and vascular endothelial cell migration. The studies found that the over expression of semaphorin 3A induced disappear or development delay in podocyte foot processes, the formation failure of ureteral branch and glomerular blood vessels, leading to glomerular dysplasia and proteinuria. Also, semaphorin 3A is considered as an important biomarker and  the potential therapeutic target in the development of kidney disease, such as acute kidney injury, diabetic nephropathy and lupus nephritis. In this paper, we made an update statement of semaphorin 3A in the development of kidney disease in recent years.

Key words: semaphorin 3A, kidney diseases, role