Abstract: Acute kidney injury (AKI) is a common clinical symptom characterized by a sharp decline in renal function in a short period of time, and the occurrence of acute kidney injury is often accompanied by a series of pathological processes such as inflammatory response, oxidative stress and apoptosis. Despite the efficacy of existing treatments, the incidence and mortality of acute kidney injury are still high due to the difficulty of early diagnosis and limited treatment methods. In recent years, advances in nanomaterials have provided new ideas for the treatment of acute kidney injury, with targeted delivery of drugs through nanomaterial carriers, which enhanced drug bioavailability and reduced side effects. This paper reviews the research progress of nanomaterials for targeted drug delivery in the treatment of acute kidney injury, focusing on the current status of preclinical research on nanomedicine therapy for acute kidney injury.

Key words: acute kidney injury, nanoparticles, targeted therapy, drug delivery